You can overload USB controllers, yes, especially if you use a lot of USB 3.0 devices on USB 2.0 hubs, since those 3.0 devices may be expecting more bandwidth than the older gen can provide. This is mostly a common problem with VR headsets with external sensors (which can eat up to like 80% of a USB 3.0 controllers bandwidth), but can happen with other devices too.
Whether that's the case here, it's tough to say without knowing quite how much you have connected to USB ports/the quality of the hub.
Some hubs are just cheap trash and have issues with some devices, I had an old USB 2 hub thing that hated most external drive, whether it was a HDD or a disc drive or a flash drive, but worked fine with controllers and headsets and stuff.
Best way to check would be to unplug the hub and try it on the motherboards USB ports, maybe unplug most stuff beyond a keyboard and mouse, and see if the problem still occurs. If so, probably bad peripherals then and not the hub.