I see where this guy is coming from. I had the same question since guides have said running Bootmii as an IOS, with Priiloader will cause a brick. No it's perfectly fine to run Bootmii as an IOS with Priiloader. They do not brick each other.
The mod author suggests to have unmodified IOS's in order to use it. The only IOS's being used IF you have only installed Bootmii, and Homebrew. Bootmii being IOS 249 (Not sure if that's the exact one I will check later.) and Homebrew running on IOS 58.
The author suggests that if you have a huge amount of IOS's being taken up for whatever reason, or being used its recommended you don't use that app due to incompatibilities.