Non-comedic:
The very first dragon you fight in Skyrim. You have to know something here, I hadn't had a proper computer for nearly 5 years now, and the computer I had back then could only run games upto Jedi Knight Jedi Academy. Therefore, this sighting was all the more amazing because at this point these were the greatest graphics I had ever seen, I was constantly amazed no matter what I saw, but this fight took my breath away.
The cinematic opening of the Witcher 2 Enhanced Edition. Fuck, that was beautiful D :
Similar to Skyrim, the first time you see Sovereign in Mass Effect, and then the very beginning of Mass Effect 3 where all hell breaks loose. Goddamn those were AMAZING moments! Also the entire final mission of Mass Effect 2, brilliant mission, where anyone could die at any moment, getting through those impossible odds with every single person alive = one of the greatest video game moments, EVER. INCREDIBLY satisfying as well!
Shin Megami Tensei Nocturne. I...I actually can't think of any particular one. The whole game in and off itself has been one of my greatest experiences, its filled with awesome moments D :
Only the beginning was a bit weak, but once the ball started rolling it kept getting better and better. Plus I went for the True Demon Ending so...that kind of speaks for itself, peeps who have played the game will know what I mean~
I can't be arsed to make separate entries for other entries in the series so ima just mention them: Devil Survivor 1+2, Strange Journey, Persona 3, Persona 2, Devil Summoner 1+2, and soon Digital Devil Saga once I finish both games :3
Ace Combat: Joint Assault. That. Final. Mission. Holy SHIT, going up against Sulejmani was absolutely amazing! One hell of a tough and incredibly satisfying fight, this game was absolutely worth it!
If only I could emulate the PS2 games properly...;_;
Aaaand that's it. All I can come up with for now, maybe I will return once I remember some more :V