Wait wait.... the region can be changed on the disc data... probably crediar know lot of info we dont know... for sure for 100% compatibility and. Stealth is better use 1:1 backup without any modification..
What I was saying, is it might be patchable while its running in ram. If the developers of the Wiikey U and Cobra Ude are able to capture the region info, after its decrypted as the "disc", (in actuality an iso running off ur hdd) is booting and running, it may be possible for them to write a command into their ODE firmware that could modify said region info as its running. Of course this is all theoretical.
As for changing region info (permanently) on the iso's themselves, that's an entirely different story. We would first need a way to fully decrypt an iso (requires any and all private keys associated with the disc encryption itself), then we have to locate the region info, figure out how to alter it accordingly and then fake sign the disc image and hope for the best. I think the easier approach would be to try on-the-fly patching as opposed to permanently patching isos first.