Nope. I tried using it with my Xbox 360 Controller without the use of XPadder or any other Controller Emulation(or sort).
Same thing with my wii u pro controller in Linux (so no special tool needed, it's seen as a standard gamepad).
It may be related to this PR:
https://github.com/citra-emu/citra/pull/1986
I try compiling both mixes, but sadly little in stable at moment, just crashes on load of game.
Also input config don't look good for pad press key .