More specific information will go a long way to help determine the problem.
*What specifically won't work? Loader won't boot? Backup won't run? ...?
*Which version of Hermes' cIOS 222/223 are you using? v4? v5?
*Which specific USB loader are you using? GX? Wii Flow?
Anymore info you can provide will narrow things down a lot.
-[]D