I just got an error "2144-0001" when I accidentally tried to open an XCI from the home menu instead of the album. The weird thing is that I've done this before and received no error. My Switch has been in handheld mode too, so it's kinda odd.
We have a thread about this specific error already. It's homebrew/cfw related and not to blame on SX OS specifically. I get it way more often when the Switch is docked and almost never when handheld. Usually when running homebrew, or when switching games in the album.