It is reported as often, or it used to be often that regional differences can also introduce enough differences to the game for it to be basically a separate game and not work. One example to parallel with emulation scene for a moment is how european version of MGS2 Subsistence for a long time could not even boot on PCSX2 while other versions US and JP were fine. The region is mentioned to just make it sure we are not just saying "YEAH US VERSION WORKS" and slap it into the arse without even seeing the other versions.Amother Question, does the region affect playability as shown on the list?