Aye then you could lock it manually somehow and plonk it in the Xbox.
It should spew out a dash error then.
Then you'll need to unlock it and prep it ;p
Or... override the TSOP with a modchip.
Must be NTFS, otherwise the ISO images won't fit.
You could format it to EXT4, if you got 2 TB worth of games, it'd be easier for the Xkey to load then.