Yes, I had an issue with the official cios and d2x fixed it!
Thanks to d2x team!
by the way, i was using herms 223 cios to avoid the wiimote lag, my hd is WD passport essential 500gb.
Installed cios249[56] v21d2x4 and cios250[57] v21d2x4. Now playing with cios 249 works fine, cio250 not tested.