terminal_illness,
What is your Wii's region? NTSC? PAL? What is your Wiikey 2 config settings and what's your firmware (1.2,1.3 etc) And did you try Eternal Darkness?
Also which media are you using? I'm using Verbatims, tried to burn the game in 2x, 4x, 8x, 16x with no luck. Also with GeckoOS...