So far i've played Mario Kart 8, Crash Bandicoot NSane, Mario Tennis, 1-2 Switch and Bayonetta 2 without any problems, so it could be a software issue.
Yesterday i injected ReiNX (The bundle that comes with the Darth Meteos sigpatches) on my 5.1.0 Nintendo Switch for the first time. So far so good, it worked perfectly, specially with things like Freeshop.
The problem i have been experiencing only happened so far with two games: Doom and Go...