I can give you perfect settings for mario sunshine no pain
. This gives full speed. EU(PAL), I run with 1700CPU and a slight GPU overclock just for the EFBSCALE x 2, If you leave it normal(X1) you dont need to boost GPU. Go to your options and change the settings in dolphin. If your still going slow try removing progressive scan, although this runs perfectly for me. Only some cutscenes may lag.
dolphin_bt_continuous_scan = "Off"
dolphin_cpu_clock_rate = "150%"
dolphin_cpu_core = "JITARM64"
dolphin_dsp_hle = "enabled"
dolphin_dsp_jit = "enabled"
dolphin_efb_scale = "x2 (1280 x 1056)"
dolphin_efb_scaled_copy = "enabled"
dolphin_efb_to_texture = "enabled"
dolphin_efb_to_vram = "disabled"
dolphin_fastmem = "enabled"
dolphin_force_texture_filtering = "disabled"
dolphin_gpu_texture_decoding = "enabled"
dolphin_ir_center = "50"
dolphin_ir_height = "50"
dolphin_ir_mode = "Right Stick controls pointer (absolute)"
dolphin_ir_width = "50"
dolphin_language = "English"
dolphin_load_custom_textures = "disabled"
dolphin_log_level = "Info"
dolphin_max_anisotropy = "0"
dolphin_mixer_rate = "48000"
dolphin_pal60 = "enabled"
dolphin_progressive_scan = "enabled"
dolphin_renderer = "Hardware"
dolphin_sensor_bar_position = "Bottom"
dolphin_shader_compilation_mode = "sync"
dolphin_wait_for_shaders = "disabled"
dolphin_widescreen = "enabled"
dolphin_widescreen_hack = "disabled"