I fear your morals are getting in the way of the debate, I dare say most would approach the world of drugs (if there even is such a thing) rather differently than you. What then is an overdose in your book? Merely an altered mental state, risk of harm, long term harm, short term harm, side effects?
Still I recall reading ancient Greek and ancient Roman texts with mention of people getting drunk (
http://www2.warwick.ac.uk/newsandevents/knowledge/arts/drinking ) so at least that long. A quick search for cuneiform mentions workers being paid in beer
http://www.newhistorian.com/sumerian-workers-paid-beer-cuneiform-tablet-reveals/6740/ so that is 5000 years, though it seems a bit light on actually being drunk.
There are many processes in most life forms that will see excess chemicals excreted if that is what you are asking, the whole system of tolerance playing to that one. Whether one exists that will limit a dose of something you wish to define as a drug, presumably under normal circumstances (there being a difference between eating something and swimming in a vat of it), to below some measure of effects is a different matter.
Also for giggles have you seen
https://news.weill.cornell.edu/news...vaccine-approved-for-clinical-study-in-humans ?