That's not true. DS should work as they do normally after a region change, since DS games are region free.Just like how region swapping can break ds games from being used though there is a fix for this.
I’m trying to determine if it’s a hardware or software issue.
What game/ cartridge are you trying to play?Again my issue is that homebrew software can see and identify the type of game inserted but it is not playable or showing on the Home Screen.
And what other cartridges have you tried so far that didn't work with this system?