Glad you confirmed this, I was scared for a second....Dios Mios 2.0 compatibility list:
(All games launched with DML Booter r22 on real nand. All games are NTSC using component cables.)
You're doing something wrong. The controller is locked during loading times. If your USB drive is slow you will get slow loading times. I would try formatting to 32k clusters if you haven't already. Sonic adventure 2 battle worked great for me, i just had to let it load