I too, experienced this. I was using an 8GB thumb drive to house my games, and while trying to run Guitar Hero Metallica, it loaded fine under 249, but the instruments were not working. When attempting to use 222 or 223, the drive is not found, and it loads forever.
I've decided to just go out...
I feel like school, back when I was actually in school, was more entertaining though, because of how much I get to interact with people, hang out with friends, and other stuff like that. All I get to talk to at work is my boring coworkers lol