It should be noted that people have been using sdcards for DS games for years without problems. My AK2.1 on my DSL still has its original card without issue. I don't see how Wii U games would be any different.
It's write AND read cycles. This isn't some DS game either. There are hundreds of textures constantly being read from the source.Yes, flash memory devices have a limited number of write cycles, but its so high that you're unlikely to actually wear them out with typical use before they get replaced with a bigger/faster version. I mean, really, just think how much wear and tear an SSD with Windows must go through. Also, Wii U games shouldn't be writing to the memory device they're stored on. They're designed to be run from discs, which are read-only.
It's only write cycles that can damage the actual media. The issue with reading the same block too much is known as "Read Disturb", but that is considered a temporary error, the block doesn't need to be marked as bad (just needs to be re-written which is often done by the controller software at first CRC error IIRC), and according to this document, is only expected to happen after "hundreds of thousands or millions" of read operations.It's write AND read cycles
It's more expensive than a HDD, but it's also faster and far less fragile. You can toss a Wii U around the back yard without worrying about damaging the memory (although it might knock something else loose), but if you did that with an X1 or PS4, it would almost surely break the drive.The Wii U has flash memory, too. So does the 3DS.