I guess you could, with some incredible lossy encoding to the point where it looks like a cutscene on the Atari 7800. For the most part, you aren't going to be able to have anything over 32MB in size (technically there is a way around that, but good luck finding a flashcart that can support anything over 32MB, much less software to allow you to do that). So just for a 20min episode of a cartoon, you'll probably have to break it up into three ROMs unless you're willing to sacrifice a lot of quality. You'd have to break it up even more if you don't want to have to wait for erasing and writing to the NOR of something like the EZ4, so you'd be stuck with a 16MB limit to write to the PSRAM instead.