The main issue with that kind of thinking, especially this generation, is that Nintendo is actually selling the Wii U at a loss, so that the sales of a game or two would make up for it (which most consumers are expected to at least buy that much). However, if people pirate in a way that does not require a game disk to launch, then you suddenly have the issue of the company that you are relying on for entertainment losing money on the sale of EVERY CONSOLE that piracy is being used on
Bringing this from Wii U Hacking Discussion, but Devolution was really ballsy with how it handled anti-piracy (i.e. needing a Wii to verify the disk and then storing it in the memory of a Wii remote, which CAN go bad, requiring you to start the process over). HOWEVER, I can see something for the Wii U working very well, so long as it was just something that required that you ripped your own disk, and then stored the information that you have the disk in an encrypted .bin file or something, then allowing you to trim/move/do whatever with the iso after it has been ripped through the USB loader