yes, is not lose since is still same save algorithm on game, patch is just replace on file system (AP fuction on some game), and is not modified on save control save, so is will work....
but if patch is for mod ROM like pokemon games, is still working too since save structure is not changed (data on event is not changed, and still not change)... if in that mod was added a few new NPC event it will broken, but you still can used it.... with lose some event i think.....
for now you can try it ... anyway i was test, and is still working for me , but it will lose some event~ item (if that mod was give a many item......)