IDK. I have heavy experience modding Skyrim on PC, but I had absolutely no experience on Switch before the Anniversary upgrade. I don't use preconverted mods from nexus, I'm converting them myself (with the toolkit from the link given in the rentry
tutorial which I believe is a bit more up-to-date than the one on nexus, especially for the hkx conversion tool). I'm not using any UI feature and just process some "drag 'n drop" on the CONVERT_ONLY bat file. I repack myself my bsa and install all the mods 100% manually.
I experienced various freeze and crash issues while learning, of course. But I also learned about the specific file formats on Switch in the same time (textures, interface text files, audio and animations). It is all working perfectly fine now, except the loading time that can dramatically increase with heavy mods.
The best advice I can offer you is the same than on any other platform where the game exists: installing confidently a huge pack of so-called 'indispensable' mods is the best way to completely f__k-up your game. Building a solid and reliable mods list or load order is a matter of patience and perseverance: one at a time...