I'll be frank....I don't know how or why this is a question in my opinion, maybe I am over thinking it, but it would be like asking if a Nintendo Switch game could run on the Nintendo 3DS, clearly and obviously that's a no, I seriously doubt homebrew would be any different from that. You can interact with DS mode using 3DS homebrew, but you aren't going to get something intended for 3DS mode to just work in DS mode. If you meant a solution similar to NTR CFW but for the Nintendo DS, then not really no, there just isn't enough legroom to make that work in the same fashion, especially since NDS software is handled differently compared to 3DS software.
You will have to modify system memory for DS Mode or you could try putting NTR CFW in TWL Patcher
Similar threads
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xtremegamer:
loving the new zelda, i started a game, it was so fucking good, so i
am waiting on my friend to get home so we can start a new one together -
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Skelletonike:
I just dislike that they don't let me choose the voices before the game starts. Happened with botw as well, had to change to japanese and restart. -
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Skelletonike:
Just scanned all my zelda amiibos, took a while but didn't get anything that cool, did get the lon lon ranch hylian fabrics though.
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K3N1:
@Skelletonike, btw I ran that custom for mgs4 on the deck I'm amazed it got that far in game -
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