Sure can bro that's how mine is setup Wii / WIIU / GameCube / N64 ect ect all. Retroarch stuff all on the same HD.. Use USB Helper to get games.. For WIIU.. Use Tecmoons wii/vc converter to get Wii GameCube... Transformed Tonto WUP files and install them using WUP GX... & simple format your HD with your WIIU system... Lastly makes sure you have 64 gig SD card or Larger to install the software