Why not just buy a house in a NON popular state or country. Buy a house in like Ohio or something, there's like nobody that wants to live there.
The trouble with some of those is not even the mighty delivery services available in this day and age don't like delivering 2 tonnes of industrial iron to my house in the woods, not to mention the trouble of just popping down to the shops when I break part of it (I live in a town of a few hundred thousand, I snap a more industrial grade machine tooling bit and I am ordering online where up north somewhere I could go down the road).
There might be no jobs for a given skillset, some might be able to telecommute (it matters little whether I send my code in from 6 time zones away or from the office of the company in some big city, harder to fix your car or build you a new house when I am far away).
There might be no support for my business - if I struggle to scrape together enough workers in a big city, or have support businesses there (trying to do everything is very hard, or maybe even something you only need from time to time, or is a bit below where you are at*) the nowhere, middle of, OH is not going to do much better. You see things like this where people want to create the next "silicon valley" and offer nice incentives to startups but neglect to have the other infrastructure in place.
*I can safely say I can set up a computer, however if I have 500 to install I am going to go to the computer shop, get a couple of the guys that know enough to plug in the right wires to the right place and let them go while I do something more important.
Not such a bother for me but many have friends, family and support networks somewhere near where they are at.
Not many bands, comedians or other types of similar live entertainment, be they big or smaller and specific, come to the middle of nowhere. You can still travel but the pain points change and while there are things I will go out of my way to see there might be a guy I liked on TV that I will happily go down the road for but taking a day out, with attendant costs, is a harder sell.
Similar story for hobbies -- not many mountains around here if I want to go mountain climbing or walking, some more the other side of the country. In your example Ohio is a landlocked place, give or take how you feel about lakes.
It may repeat again -- I am about two hours from London, 20 years ago there were a few that commuted, mostly high paid or specific skill people that might have lived in hotels. Today the commuter band is way past here (a couple of years back I found myself stuck on a train platform about 40 minutes the other way and was shoulder to shoulder with commuters, at about 4am) and many companies have very big satellite offices here. For some that might be a good thing as you could flog your house on with the presumed massive increase in value, however you have to do that right as everything else tends to creep up in price -- a couple of years back I was in Washington state, not far from where Microsoft and the like are headquartered and knocking about with the people doing city works. A few doing those jobs had inherited houses from parents or similar and the taxes the city was levelling to keep the microsoft peeps happy (most places just try to de-ice the main streets and have a park not filled with rubbish, these de-iced everything with a whole fleet and did proper gardening in the parks and roadsides) were somewhat higher than a county or two over (they in turn commuted to do shopping rather than staying some kind of local).
Some of those are perhaps a bit whiny for my taste, however it was not places are impossible to live in (in many places rent is somewhat lower than a mortgage payment) and here is how to sneak around that but something to consider as an alternative to that. Or if you prefer work to live, not live to work and a house in the suburbs with a couple of kids and a white fence is both my nightmare and certainly not the key to happiness for everybody.