EU games are in PAL. US games are in NTSC. Well, unless they're region free or something.
Most of the time, EU releases are multiple languages and US ones are usually either just English or English, Spanish, and French (English for America and most of Canada, Spanish for South America, and French for Quebec). EU releases range from English to German to French to Italian and so on.
And every now and then, depending on the game, EU releases will have censorships, like in No More Heroes.