It's a patch for Ocarina of Time n64? If it's compiled into it's own rom, it might work with Retroarch. If it's only a patch you must somehow add on top of the rom.. IDK. I guess you'd build your own patched rom.
Let us know if you get it working! I may try this myself when I have more free time.
Edit: just found a .z64 in some spanish youtube video. No clue if it's legit or if it would even work in RetroArch, but there may be some pre-patched roms floating around. Patching it yourself is probably the safest way to do it.