Syscheck looks good, though you're using beta52: Colours doesn't like usb port1, check your drive is in usb port2, it's one of the very few games that won't run otherwise.
Failing that, could be a bad dump, also you're trying Sonic Colours (so PAL, rather than NTSC 'Colors') - have you set the region to one of the pal variants in usbloadergx?