Am I the only one who finds the 'reason' ludicrous?
I mean we just got Devil survivor 2! It jammed packed with all these religious and myth based demons, and yadda yadda.
Oh yeah it's also rated effin 'T' for Teen... not to mention this is number 2 in the series. >.>
Shin Megami Tensei games are completely different, they don't make fun of anything in the bible they just darken a bit of the stuff, myths, demons and all that are normal in games, nothing wrong with it, there's a demon called Lucifer, sure, but he's one of the strongest demons and they depict him with wings, charismatic and noble, which is in accordance with how he was before defying God.
Several games use religious elements, but they rarely use something in the way Isaac does.