I could see people buying ME3 for the wii u without any prior knowledge of the series. The story is shit anyway, so they aren't missing anything by skipping the gameplay of the first two. I'd say the gameplay was best in the third. So, might as well just play that.
LOL SO HARDCORE. Sorry there's not enough kawaii~ anime girls for you.
But yeah, I criticized the PS3 version of ME2 pretty bad for not having the first game and this is even worse. Anyone who played the first two games and liked them would've bought this on one of three other consoles already. If BioWare just ported over another game to the Wii U it'd have been so much better. I mean they're coming out with like a new Command and Conquer, why not make the PC master race squirm in their pants a little with a Wii U release?