Nice eh.
Ok I define 'nice' anime as being eligible for mom dad brother and sister, no one being able to call it out in any way for anything negative.
Thus pantie shots not the end of the world, but being ABOUT panties gets you disqualified.
Nudity. One nude scene in a hot springs event where they are clearly nude, but you didn't really see anything is not a foul. Pointless tittie scenes where it's tits for the sake of it, disqualified.
Excessive blood and gore, disqualified.
Foul language, disqualified.
More than one sexuality choice in your face choice personality disqualified. Yes I am disqualifying shows that make it too big of a focus. We get it, anime has homosexuals, move on.
So what is left?
Well it likely will 'look' like girly anime shows to some. Keep in mind, I know several very large adult males willing to correct you.
Air TV a wonderful story.
Clannad and Clannad After Story. 50 shows of pure gold.
KimiKiss Pure Rouge, fantastic stuff.
Azumanga Daioh, more funny than I can describe.
Negima, a funny magic based drama.
Madlax, cool action drama.
Noir, cool action drama.
Full Metal Panic. Nice blend of funny and action drama.
The above are all out on dvd as easy to purchase box sets which means English dialogue for those of us not totally into subs.
It's not a complete list, heck a complete list could take me another hour.