Hacking I think the answer is no. but...

[caffeine_demon]

as I said i think the answer is no, but is there an accessory available to us original gameboy / gameboy color carts on the ds?

 

[Rayder]

An emulator called Goomba will play GB/GBC games, but it's for slot2 devices....unless it's been recompiled for DS to run on a slot1. I haven't looked into it for a while.

http://www.webpersona.com/goomba/

 

[Mooney]

LameBoyDS is pretty good at emulating GB/GBC.

I don't think there are any devices that let you play actual GBC carts on the DS, though.

 

[cubin']

yea brah u can play gba on nds

 

[DanTheManMS]

GB and GBC carts don't work because the z80 processor that handled them is completely missing in the DS. The GBA and GBA SP had both the ARM7 processor and the z80 processor inside, but for the Gameboy Micro and DS they took it out to save space.

The only possible hardware solution I can think of is the GB Bridge, but I don't think it'll fit into a DS correctly. You'd need an old-fashioned Flash2Advance cartridge to use it anyway.