Note that this setting does not apply to you if you don't have a slot-expansion pack. If you don't know what that is, you probably don't have one.
AUTO vs ALWAYS in relation to the NOR, refers to a setting with GBA games when you run them natively in AKAIO along with a 3in1 expansion pack. The NOR is the memory of an expansion pack (like the slot-2, EZ Flash 3in1) which loads games of a larger file size. PSRAM is another area of memory which loads games of a smaller game size. When the NOR is set to AUTO, AKAIO will decide if the game is small enough to go into the PSRAM or have to be flashed to the NOR. ALWAYS will make is so that even the small games will flash to the NOR.