Duke Nukem 3D has been successfully ported to the NDS by GPF!!!
Lookie:
Source: DCEmu
Downloads available at THIS PAGE but it kinda sucks since you have to sign up for the forums to download. Maybe someone with an existing DCEmu forums account can download and rehost on a direct download site? Pwetty Pwease?
Lookie:
GPF said:Release Info
  Port of the Duke3d from the GP2x port
  The home page of the NDS port is http://gpf.dcemu.co.uk .
  dpad move Duke
  a fire
  b jump
  x look up
  y look down
  lefttrig strafe left
  righttrig strafe right
  select use item
  start select
  touchscreen look around, change weapon
  dldi patch .nds and copy it and defs.con, game.con, user.con, duke3d.grp and supplied duke3d.cfg to /duke3d directory of card. might be case sensitive with Uppercase. It still needs sound added and network support, but is playable with your own provided shareware .grp or full version .grp file.
  thanks and enjoy,
  Troy Davis(GPF)
  http://gpf.dcemu.co.uk/
Source: DCEmu
Downloads available at THIS PAGE but it kinda sucks since you have to sign up for the forums to download. Maybe someone with an existing DCEmu forums account can download and rehost on a direct download site? Pwetty Pwease?