Switch uses 128KB (SanDisk Ultra 128GB A1 reported by other users), but it might be just depending on the card settings as Switch like windows probably read SD factory settings and use it automatically.
The more the cluster size, usually it gives a better performance specially to write speed, but the best is probably to use the native setting.
Also the higher you chose, small files will waste more space, though most likely we wont have much little files on the M-SD for the Switch so you won't end with much lost space...
ps: Just try the maximum, if its working worse, use default settings...