It's been my experience that many PAL games don't cooperate with Make-Multi on my NTSC-U Wii. But then, burning them directly to a DVD+RW has worked many times.
And just becase a NTSC game works on PAL, does not necessarily mean the PAL version will work on NTSC systems. It just takes some trial and error. That's why rewritable discs come in very handy.
I have played Starfox Adventures with my Wiikey ok. I didn't get terribly deep into the game, so I don't know if the audio streaming bug doesn't kick in until later, or something.