I homebrewed my Wii yesterday and downloaded New Super Mario Bros. Wii onto a USB drive (tried both NTFS and FAT32) and decided to use Reggie Level Editor to change level 1-1 a bit as a test. I tested it on Dolphin emulator and it worked fine as expected, but when I replaced the original game .wbfs file in the USB drive and loaded it on the Wii it didn't work. I also tried it with a .iso file and again, it worked in Dolphin but the Wii can't load it. Dolphin loads it as expected but the Wii doesn't even reach the part where it tells you to wear your Wiimote straps, it just boots back into the homebrew channel.