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Joe Biden is now officially the 46th President of the United States of America

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notimp

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I heard current vaccines will be enough to fight mutations. They are mutated enough to be vastly different.
What I heard is the following.

This goes for mRNA vaccines. This might not go for the Astra Zeneca vaccine. (Still in testing). (Johnson and Johnson is the same 'kind' - might produce different results, dont know.)

Furthermore, the new strain from Great Britain is 'pretty close' in terms of the receptor protein - so likely to be covered by excisting vaccines (thats a yes on both mRNA afair, and a dont know on AstraZeneca).

The new strain from Brasil/South africa (sorry I'm blanking on origin), mutated by quite a bit, and might not be covered by any of them.

That said, AstraZeneca is already working on modifying their vaccine so it covers the new mutations - which is a pretty straight forward thing - for the method that vaccine uses, because they can basically copy the mutation steps in the RNA, and put it into the vaccine -- and thats a process they already do for the annual flue vaccine f.e. So process is easy - but this still means - delay (another year)?

Depends on propagation. (Its not that wide spread in Europe as of now, so it might be fine, if it arrives before the next winter - f.e.).
 
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Lacius

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There are some reports there is a 50% reduction in efficacy & they already didn't stop you catching covid19.

Vaccination isn't going to end this, no matter what Trump said it isn't just going to disappear.

The UK government is investing in a production facility that will be able to produce enough vaccine for everyone in the UK within 6 months. It's hoped it will be open by christmas.

We're going to be vaccinating everyone every year for the foreseeable future.



Unlikely, even the mutations we have now. Let alone what mutations we might have in another couple of months.



No, not true at all. Most people don't get symptoms, of those who do then most don't die and it takes a while. The current mutations don't actually increase the numbers of death by a huge amount relatively speaking. We are still a long way from covid19 from mutating to be something more like ebola with a short period before everyone gets really sick and dies.

It could become more deadly and more transmissible. It's too early to tell, because the mutations have only recently taken hold.
Yes, the vaccines do indeed offer resistance against catching COVID-19. In addition, with the efficacy likely lasting approximately 2-4 years, we might not see a yearly vaccine. Instead, we might see a vaccine every few years. We will see.
 
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omgcat

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Since Joe Biden was sworn in, 8,529 people have died from Covid
on average, it takes 2 months from infection to death. those 8+k people were sick way before biden got in office my friend.
great bait, makes this image look real:

a5EPZXq_460s.png
 
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smf

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Yes, the vaccines do indeed offer resistance against catching COVID-19.

What do you mean by "catching"

https://www.lbc.co.uk/news/can-you-still-spread-covid-19-if-youve-had-the-vaccine/

As stated on the government website, it is only known for sure the Covid vaccine can protect you from becoming seriously ill, not others who are yet to be vaccinated.

At present, it is unknown if it will stop you from catching and passing on the virus. However, experts do expect it to reduce this risk.
 
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SG854

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What I heard is the following.

This goes for mRNA vaccines. This might not go for the Astra Zeneca vaccine. (Still in testing). (Johnson and Johnson is the same 'kind' - might produce different results, dont know.)

Furthermore, the new strain from Great Britain is 'pretty close' in terms of the receptor protein - so likely to be covered by excisting vaccines (thats a yes on both mRNA afair, and a dont know on AstraZeneca).

The new strain from Brasil/South africa (sorry I'm blanking on origin), mutated by quite a bit, and might not be covered by any of them.

That said, AstraZeneca is already working on modifying their vaccine so it covers the new mutations - which is a pretty straight forward thing - for the method that vaccine uses, because they can basically copy the mutation steps in the RNA, and put it into the vaccine -- and thats a process they already do for the annual flue vaccine f.e. So process is easy - but this still means - delay (another year)?

Depends on propagation. (Its not that wide spread in Europe as of now.).
It's alot of catch up and trying to keep up with mutations. Even if we have the best production and distribution methods keeping up with mutations is another thing. But it could be similar to the common flu. We keep up with that yearly.
 

omgcat

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They prevent you from "getting sick" with covid 19. That doesn't mean you can't be a host.

it effectively prevents serious complications and death. that's the point. if we get everyone vaccinated much less people will be hospitalized or dead.
 
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notimp

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They prevent you from "getting sick" with covid 19. That doesn't mean you can't be a host.
From showing the worst symptoms yes - so they are beneficial. In any case.

I've heard that as well but currently am unsure for what vaccine that statement was made...

This afair is for new mutations. A working vaccine for those new strands would also mean, it prevents you from spreading it.
 

omgcat

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It's alot of catch up and trying to keep up with mutations. Even if we have the best production and distribution methods keeping up with mutations is another thing. But it could be similar to the common flu. We keep up with that yearly.

it took them less than 48 hours to sequence the genome of the original covid virus and making a working vaccine. the mRNA platform they are working on can be programmatically updated based on most common sequenced strains. fuck they could automate the process entirely once an update vaccine is proved safe.
 

Hanafuda

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Hanafuda seems blinded by loyalty to Trump and hate of Biden.


I never even liked Trump, not as a person. Caustic ass. Dig enough through my post history and you'll find me saying so. But I don't vote for politicians on personality, or character. The deregulation of administrative agency procedures, freeing up the fracking industry so the USA could break its dependence on Saudi and Russian oil, no new wars and actual progress toward peace in the Middle East, the booming economy (pre-Covid, not to mention the incredible recovery speed last fall) and lowest unemployment across all demographics pretty much ever ... that I liked. I would vote for him again, but I would vote for Joe Biden if he promised to do the same things.
 

smf

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A working vaccine for that strand would also mean, it prevents you from spreading it.

As it's not know whether the current vaccines stop you spreading the existing strains, then I don't think you can expect it to work on new strains. Especially when there are reports the current vaccines only have 50% efficancy

I don't know if it affects both vaccines the same, but the UK is going to run out of pfizer and moderna doses soon and then it's all oxford all the way. So they are unlikely to single one type of vaccine out at this point.

I never even liked Trump, not as a person. Caustic ass. Dig enough through my post history and you'll find me saying so. But I don't vote for politicians on personality, or character. The deregulation of administrative agency procedures, freeing up the fracking industry so the USA could break its dependence on Saudi and Russian oil, no new wars and actual progress toward peace in the Middle East, the booming economy (pre-Covid, not to mention the incredible recovery speed last fall) and lowest unemployment across all demographics pretty much ever ... that I liked. I would vote for him again, but I would vote for Joe Biden if he promised to do the same things.

You say no new wars. I didn't realise the US were at war with Iran.

https://www.bbc.co.uk/newsround/50982493

Fracking is an environmental hell hole, but Trump loves the oil industry.

Thing is you do sound like you are blinded by a love of Trump. Maybe you just love all his loser ideas.
 
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Cryoraptor

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While the vaccines might not offer the same level of resistance against the new strains, there's evidence the vaccines are still at least somewhat effective against them.
Let me explain this for some who don't understand it yet:

Immunity is not an absolute. It's a blurred continuum. Generally speaking, with viruses, immunity works by the immune system building antibodies that can connect to the protein spikes of the virus. Those protein spikes are very complex, which means a sudden flip to a totally different protein build is unlikely. Generally, if a virus gets a mutation in relation to its protein spikes, one small part of it will change. That will make some of your antibodies against the virus ineffective, but some will still work. Your body retains some sort of resistance to the pathogen. 'Resistance' and 'immunity' are not the same things. 'Resistance' implies that something doesn't have much of an effect on you, while 'immunity' implies that you are completely invulnerable. The reason why you don't die of colds, but you can still get ill from them is because you have resistance to most of the viruses that cause upper respiratory disease. Part of that resistance is inherited through thousands of generations of coexisting with those viruses, and part of it is through exposure. If you get a cold this year, you will retain some sort of resistance to the virus responsible from the cold you had last year or the year before. Hence, you sometimes get a stuffy nose and a headache (a lot of the time no symptoms at all), but you don't really feel that ill and you fight it off with relative ease, and your body updates its adaptive immunity to the new mutations the virus gained this year. Rinse and repeat.

COVID doesn't exactly work in that way, but it follows a similar basic model. The new variants will most likely have a small difference in their overall protein structure, but the other 99% is identical to the older variant. Currently we don't think it mutates exceptionally fast, certainly not as much as rhinoviruses, the main culprits of the common cold, so these changes will occur at a considerably slower rate than most other widespread viruses. This means the current vaccines will continue to be effective at preventing severe disease for quite some time into the future, possibly for the rest of the person's life if they are able to come into contact with new COVID strains regularly and keep updating their adaptive immunity without falling more than mildly ill. When I say 'mildly', I mean getting a headache or a cough for a couple of days, not 'mildly' as in as bad as the flu and just staying out of the hospital. Also, as Lacius points out, the faster we roll out the vaccine to as many people as possible, the more effective it will stay, as less hosts mean less chances of changing its structure in a way that somehow helps the virus to circumvent the vaccine. This is why people not vaccinating their kids for measles and other such illnesses is such a bad thing; right now it's not that common, so most people will stay resistant, but if more and more people start getting it because people aren't vaccinating, the virus will begin to mutate to a point where the MMR isn't effective against it anymore, and a new measles epidemic, and likely pandemic, will ensue, and millions of children and most likely adults too will die, and millions more children will be left permanently deaf. Measles spreads crazy fast: about twice as fast as COVID does, and COVID spreads about twice as fast as regular human upper respiratory infections (RHURI? Can that be a thing now?). Measles is no joke.

Back to the topic at hand, a new variant or 10 isn't the end of the world. The vaccine will likely offer a significant amount of protection against these slightly different variants. 'But muh new variant' isn't a good reason to not take the vaccine, in fact that directly helps the virus to mutate more and worse than diversify, speciate into entirely different species, at which point a single vaccine becomes almost impossible. Don't be an idiot, take your shot.
 

Valwinz

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I love how as soon a Biden is president China starts to mess with Taiwan more is like they know he wont do anything lol Beijing Biden
 

smf

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'But muh new variant' isn't a good reason to not take the vaccine, in fact that directly helps the virus to mutate more and worse than diversify, speciate into entirely different species, at which point a single vaccine becomes almost impossible. Don't be an idiot, take your shot.

Exactly. The same as "I'll let everyone else have the vaccine and rely on herd immunity" is dumb because they won't be the only idiot doing that & you'll end up with the same issue.

I love how as soon a Biden is president China starts to mess with Taiwan more is like they know he wont do anything lol Beijing Biden

Trump didn't do anything other than self harm.

Taiwan seem to have the situation under control.
 
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Hanafuda

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i love how "reasonable" trump supporters start every conversation with a long-form disavowment, then go on to praise his every move
if you just admitted you love the guy we'd respect you more

I have mixed feelings about Trump. Been seeing his face since the early 80's. Always thought he was a bombastic ass, but I don't live vicariously through the television / pop culture like most people so I didn't care. (I don't watch pro sports, and I don't watch ANY American television with commercials, since 1987. I couldn't care less about celebrity endorsements, what happened on the last episode, etc.) But given the choice between Trump and Hillary Clinton in 2016 ... no contest. I would vote for a bag of flaming dogshit over Hillary Clinton. I was skeptical of whether Trump would follow through after being elected, since he had been a Democrat, and 3rd party ... not consistent. But he did nominate good conservative judges, he did follow through on the deregulation, he did produce a booming economy, fuel independence for the US for the first time ever, and very low unemployment. So yes, I supported him in re: job performance. But love the guy? No, that's not my personality on any aspect of culture. No religion here, no fanaticism. No red caps, either lol.

I mean, do you really "love" Joe Biden??? Probably not. But you'll take him every fucking day over Trump, amirite?
 
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notimp

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The South African variant carries a mutation called E484K, among others. ... Scientists have tested the Pfizer Covid vaccine against one of the mutations found in the South African variant, called N501Y, using blood samples from 20 people. In that preliminary study, vaccination appeared to work against the mutated virus
Thats Pfizer, which is mRNA - correlate this with:

https://www.indiatoday.in/coronavir...ne-system-warn-researchers-1761619-2021-01-22

and:
https://web.archive.org/web/2021012.../20/health/coronavirus-variants-immunity.html
 
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