Genetically modifying a virus scares you... Jebus.
We have to talk about this for a while after...
Astra Zeneca resumed its study in the UK 4 hours after it announced it was halted, which is - unexpected...
https://www.statnews.com/2020/09/12/astrazeneca-covid19-vaccine-trial-resumes-uk/
see also:
https://www.nature.com/articles/d41586-020-02594-w
Also, they crammed in a meeting with financiers (afair) shortly before the first press statement. This is how financial pressure looks like.
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Here is the rundown on what happened. Side effect is rumored to be Transverse Myelitis in 'one or two cases' (out of 17.000 plus - but this is potentially more than a statistical snafu.)
Transverse Myelitis is an inflammatory illness that could be caused by several factors, one of which is an auto immune response. This means, potental causes could be:
- Virus (in the vaccine, or a different one entirely) causes the immune reaction
- Surface level molecules are similar to your bodys, training antibodies to go after your bodies cells (chance accident)
- Overactivity of you bodies immune system (T cells) also can cause inflamation
- Overproduction of your bodies anti-bodies can lead to them accumulating in the spine (where Transverse Myelitis takes place prominently), which causes the issues above.
Astra Zeneca also denied to confirm, that journalistic research was correct, and it had been a case of Transverse Myelitis that caused the trial to stop. And it is unclear, if there is one case, or there are two cases (rumored) currently.
General probability of Transverse Myelitis after any vaccination is 1:250.000 (so extremely rare).
Which means - this is a cluster-f to figure out 'what caused it' especially in short time. So the exact opposite of great.
This is related to one out of nine vaccine candidates currently in testing (candidate AZD1222) although it is a prominent one (its the 'Oxford cadidate' and Astra Zeneca is a _major_ manufacturer).
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Regarding 'genetically modifying a virus' making people worried. You do that to reduce risk all over the board. If your process includes 'growing more Covid-19 in cellular cultures, then trying to kill it, before you put it into a tube...' more problems are expected to arise. Producing genetically modified (not very complex) organisms can be more safe, than other forms of vaccine production.
The emotional reaction comes from GMO food, and the idea that you put something 'unnatural' in your body - again. The issue here is, that GMO foods also are largely unproblematic (after they have undergone safety trials (do they produced some unexpected chemical compound as a result? No? Fine.).
Issues with GMO food arise from you not being able to tell how it will react in natural mutation chains, down the road - which is why you design the reproductive capability out of GMO anything usually. Which leads to economic interdependence, if farmers cant grow their crops 'generationally'. (One bad harvest, and you are buying seeds from a manufacturer again, hopefully with insurance money.)
Roughly this:
Scientists Say GMO Foods Are Safe, Public Skepticism Remains
https://www.nationalgeographic.com/...gmo-foods-are-safe-public-skepticism-remains/
edit: If someone wants to cross reference timetables, conference call with investors was on wendesday morning.
https://www.statnews.com/2020/09/09/astrazeneca-covid19-vaccine-trial-hold-patient-report/