Edit. I see a whole conversation has gone on. I will leave my reply up though.
Unless I buy ultra fancy ones pendrives I tend to write off after about a year of general use and unless you are doing something like running a standard OS (they are often a bit slow but you can run an OS one one if you set it up properly) on one then chances are you will leave it in a laptop and break it long before then.
I will assume you routinely have to store and run 4 gig or large files on the drive, I have not really had this but I stopped playing with isos years ago and most of the time you can split a file easily enough with something like 7zip (if you do not compress it then it takes the same amount of time as copying it).
NTFS is widely supported, exfat is not as rare as some of the linux/BSD specialist stuff but can be tricky if you are not on Windows and some mac stuff. Stock NTFS on a pendrive I can see being less than ideal for a few reasons but not enough to really matter on these sizes and with standard options.
To that end I will have to ask you what you want to do? If it is just for your personal use on your machine as a backup of sorts or transfer between machines you control then you might even consider something else like ext3 (
http://www.ext2fsd.com/ being able to see it in windows if you want it to).
If you plan to use it as a windows repair type and/or day to day usage probably NTFS.
Similarly you might have trouble on some TVs and other embedded devices if you use exfat.
Whatever you do make sure you eject the drive properly on every occasions, even if you have "optimise for quick removal" enabled.
LOL
