Most DS games are designed so that when you use the stylus, you don't need to use the ABXY and L buttons. (If your a lefty, then its the other way around.) Therefore you don't need 3 hands. You can have 1 hand on the classic controller to use the D-Pad and L button, and one hand on the Wii remote. If your not using the stylus, then you can have both hands on the classic controller and let the Wii remote dangle from the wrist strap. But like I said, it isn't even possible yet.