it works with other games?
it happens only with tale of symphonia?
you didn't provide a lot of details.
You didn't tell which version of the loader you are using, you didn't tell which version of nintendont.
You didn't tell if it's doing it only for this game of for all games.
you didn't tell which cheats you enabled (some might require edition on computer first, other might not work together, etc.)
You didn't tell which other option you enabled for nintendont or if you tried to enable/disable them too.
you didn't tell if it's really a USBLoaderGX issue by telling if nintendont is working fine when launched from HBC with autoboot and cheatcode enabled