sky3ds works by copying the hardware behaviour of a retail cartridge, there supposedly is no software exploit envolved
as such, it also copies the region information of the game without a software way of circumventing it, so for now no region free unless someone can figure something out
(I could imagine, that you maybe could decrypt the rom, change the region info and re-encrypt the rom again and then... maybe... it could work? o.O
edit: nevermind, yeah gamesquest just said it... it won't run edited roms lol)